Predictive value of preoperative inflammatory indexes for postoperative early recurrence of hepatitis B-related hepatocellular carcinoma

Objective To investigate the predictive value of preoperative neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), systemic inflammation response index (SIRI), and immune (SII) for early recurrence after liver resection in patients with hepatitis B-related hepatocellular carcinoma. Methods A retrospective study was conducted on 162 who underwent carcinoma (HCC) between January 2013 April 2016. The Youden utilized to calculate optimal cut-off value. Pearson Chi-square test applied analyze relationship inflammatory indexes common clinical pathological features. Kaplan-Meier method Log-Rank were implemented compare recurrence-free survival rate within 2 years population. Cox regression analysis used identify risk factors postoperative recurrence. Results best values SIRI, PLR, NLR SII 0.785, 86.421, 2.231 353.64, respectively. Tumor diameter, degree tumor differentiation, vascular invasion, SIRI>0.785, PLR>86.421, NLR>2.231 SII>353.64 Combining above seven construct a joint index, AUC prediction model 0.804. areas under ROC curves NLR, 0.659, 0.725, 0.680, 0.723, There no significant difference ability single models, but performance significantly higher than that models. lower had longer years. Conclusion CIP, constructed by combining NLP features, can better predict HBV-related HCC surgery, which is beneficial identifying high-risk assisting clinicians make choices.